MPV - Mean Platelet Volume
MPV (Mean Platelet Volume) is a parameter reflecting the average size of platelets in the blood. It is one of the additional platelet-related parameters in the complete blood count and helps assess platelet activity and maturity.
Normal MPV values:
- 7.5 – 11.0 femtoliters (fL)
- Normal ranges may slightly vary depending on the laboratory
What MPV indicates:
- High MPV indicates the presence of large, young platelets. This may suggest increased bone marrow activity or accelerated peripheral platelet destruction.
- Low MPV indicates predominance of small, old platelets or impaired platelet maturation.
MPV is increased in:
- Thrombocytopenia (response to rapid platelet loss)
- Myeloproliferative disorders (e.g., essential thrombocythemia)
- Diabetes
- Atherosclerosis
- Thyroid diseases
- After blood loss or surgical operations
MPV is decreased in:
- Anemias (especially iron deficiency anemia)
- Chronic inflammations
- Autoimmune diseases
- Megaloblastic anemia (B12/folate deficiency)
- Infections and sepsis
Clinical significance:
- High MPV may indicate a risk of thrombosis
- Low MPV may be associated with impaired platelet production in the bone marrow
- MPV assessment is performed only together with total platelet count (PLT) and other parameters (PCT, PDW)
How to take the test:
- Blood should be drawn fasting, preferably in the morning
- Physical and emotional stress can affect the results